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Drug ReportsZoptarelin doxorubicin
Zoptarelin doxorubicin
Myocet, Pegylated (zoptarelin doxorubicin) is a protein pharmaceutical. Zoptarelin doxorubicin was first approved as Caelyx pegylated liposomal on 1996-06-20. It has been approved in Europe to treat breast neoplasms, kaposi sarcoma, multiple myeloma, and ovarian neoplasms.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
neoplasmsD009369
urogenital diseasesD000091642
cardiovascular diseasesD002318
hemic and lymphatic diseasesD006425
skin and connective tissue diseasesD017437
endocrine system diseasesD004700
immune system diseasesD007154
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FDA
EMA
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Drug Products
FDA
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New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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FDA
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Clinical
Clinical Trials
366 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Ovarian neoplasmsD010051EFO_0003893C56416236211136
Ovarian epithelial carcinomaD000077216——34472728104
Breast neoplasmsD001943EFO_0003869C501861135791
LymphomaD008223—C85.9926101445
Multiple myelomaD009101—C90.0102341—29
Plasma cell neoplasmsD054219——102341—29
LeukemiaD007938—C953531112
Non-hodgkin lymphomaD008228—C85.92711112
Precursor cell lymphoblastic leukemia-lymphomaD054198———351110
Lymphoid leukemiaD007945—C91—331—7
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Fallopian tube neoplasmsD005185——242216——52
RecurrenceD012008——12189—234
CarcinomaD002277—C80.015186——34
Peritoneal neoplasmsD010534——785——17
SarcomaD012509——694—117
Endometrial neoplasmsD016889EFO_0004230—2102——13
Endometrioid carcinomaD018269——564——12
Serous cystadenocarcinomaD018284——483——12
Triple negative breast neoplasmsD064726——461——11
Large b-cell lymphoma diffuseD016403—C83.3261—211
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
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NeoplasmsD009369—C801810——125
Neoplasm metastasisD009362EFO_0009708—35———7
PlasmacytomaD010954—C90.336———7
CystadenocarcinomaD003536——42———6
Prostatic neoplasmsD011471—C6123———4
Follicular lymphomaD008224—C8212——14
Liver neoplasmsD008113EFO_1001513C22.022———4
Urologic neoplasmsD014571—C64-C6822———3
Stomach neoplasmsD013274EFO_0003897C1612———3
Urinary bladder neoplasmsD001749—C67—2———2
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
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Total
Colorectal neoplasmsD015179——2————2
Plasma cell leukemiaD007952—C90.11————1
B-cell lymphoma marginal zoneD018442—C88.41————1
Aids-related lymphomaD016483EFO_1001365—1————1
Brenner tumorD001948——1————1
OncogenesD009857——1————1
Head and neck neoplasmsD006258——1————1
Small cell lung carcinomaD055752——1————1
Ovarian diseasesD010049——1————1
Intestinal neoplasmsD007414—C26.01————1
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
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Total
ParesthesiaD010292HP_0003401R20.2————11
Carcinoma in situD002278—D09.9————11
VomitingD014839HP_0002013R11.1————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameZoptarelin doxorubicin
INNzoptarelin doxorubicin
Description
Zoptarelin doxorubicin (developmental code names AEZS-108, AN-152) consists of doxorubicin linked to a small peptide agonist to the luteinizing hormone-releasing hormone (LHRH) receptor. It has been developed as a potential treatment for a number of human cancers. The LHRH receptor is aberrantly present on the cell surface of approximately 80% of endometrial and ovarian cancers, 86% of prostate cancers and about 50% of breast cancers. Whereas in normal tissues, expression of this receptor is mainly confined to the pituitary gland, reproductive organs and hematopoietic stem cells. To a lesser extent the LHRH receptor is also found on the surface of bladder, colorectal, and pancreatic cancers, sarcomas, lymphomas, melanomas, and renal cell carcinomas.
Classification
Protein
Drug classprehormones or hormone-release stimulating peptides; antineoplastic antibiotics (daunorubicin type)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)COC(=O)CCCC(=O)NCCCC[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1
Identifiers
PDB—
CAS-ID139570-93-7
RxCUI—
ChEMBL IDCHEMBL3544954
ChEBI ID—
PubChem CID16134409
DrugBank—
UNII ID27844X2J29 (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
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Trends
PubMed Central
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Safety
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619 adverse events reported
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