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AboutPricing
Drug ReportsZoptarelin doxorubicin
Zoptarelin doxorubicin
Myocet, Pegylated (zoptarelin doxorubicin) is a protein pharmaceutical. Zoptarelin doxorubicin was first approved as Caelyx pegylated liposomal on 1996-06-20. It has been approved in Europe to treat breast neoplasms, kaposi sarcoma, multiple myeloma, and ovarian neoplasms.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
neoplasmsD009369
urogenital diseasesD000091642
cardiovascular diseasesD002318
hemic and lymphatic diseasesD006425
skin and connective tissue diseasesD017437
endocrine system diseasesD004700
immune system diseasesD007154
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EMA
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FDA
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Abbreviated New Drug Application (ANDA)
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Clinical
Clinical Trials
195 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Ovarian neoplasmsD010051EFO_0003893C562425111358
Breast neoplasmsD001943EFO_0003869C50113464349
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Fallopian tube neoplasmsD005185——18115——27
Ovarian epithelial carcinomaD000077216——752—213
SarcomaD012509——561—111
LymphomaD008223—C85.9661——9
Endometrial neoplasmsD016889EFO_0004230—171——8
Endometrioid carcinomaD018269——521——6
Precursor cell lymphoblastic leukemia-lymphomaD054198—C91.0—24——6
Peritoneal neoplasmsD010534——231——5
Acinar cell carcinomaD018267——111——2
Renal cell carcinomaD002292EFO_0000376——11——2
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369—C8093———11
Multiple myelomaD009101—C90.0410———10
Plasma cell neoplasmsD054219——25———6
Triple negative breast neoplasmsD064726——32———5
Liver neoplasmsD008113EFO_1001513C22.022———4
Uterine cervical neoplasmsD002583HP_0030159—14———4
Prostatic neoplasmsD011471—C6122———3
LeukemiaD007938—C9511———2
Stomach neoplasmsD013274EFO_0003897C1611———2
Esophageal neoplasmsD004938—C1511———2
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
CystadenocarcinomaD003536——3————3
Hepatocellular carcinomaD006528—C22.02————2
Plasma cell leukemiaD007952—C90.11————1
Brenner tumorD001948——1————1
Pancreatic neoplasmsD010190EFO_0003860C251————1
Head and neck neoplasmsD006258——1————1
Small cell lung carcinomaD055752——1————1
CarcinomaD002277—C80.01————1
Ovarian diseasesD010049——1————1
Myelodysplastic syndromesD009190—D461————1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameZoptarelin doxorubicin
INNzoptarelin doxorubicin
Description
Zoptarelin doxorubicin (developmental code names AEZS-108, AN-152) consists of doxorubicin linked to a small peptide agonist to the luteinizing hormone-releasing hormone (LHRH) receptor. It has been developed as a potential treatment for a number of human cancers. The LHRH receptor is aberrantly present on the cell surface of approximately 80% of endometrial and ovarian cancers, 86% of prostate cancers and about 50% of breast cancers. Whereas in normal tissues, expression of this receptor is mainly confined to the pituitary gland, reproductive organs and hematopoietic stem cells. To a lesser extent the LHRH receptor is also found on the surface of bladder, colorectal, and pancreatic cancers, sarcomas, lymphomas, melanomas, and renal cell carcinomas.
Classification
Protein
Drug classprehormones or hormone-release stimulating peptides; antineoplastic antibiotics (daunorubicin type)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)COC(=O)CCCC(=O)NCCCC[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1
Identifiers
PDB—
CAS-ID139570-93-7
RxCUI—
ChEMBL IDCHEMBL3544954
ChEBI ID—
PubChem CID16134409
DrugBank—
UNII ID27844X2J29 (ChemIDplus, GSRS)
Target
No data
Variants
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Financial
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Trends
PubMed Central
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Safety
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No Black-box warning
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622 adverse events reported
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